ICAN Urges Toxicology Review of Vaccine Ingredients Like Aluminum and Formaldehyde


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ICAN has nominated four vaccine ingredients—aluminum, mercury, formaldehyde, and phenol—for review by a federal toxicology agency.

The Agency for Toxic Substances and Disease Registry (ATSDR) filed a public notice asking for nominations for which hazardous substances it should evaluate next. ICAN submitted a comment nominating the following four substances, which are common vaccine ingredients:

  • Aluminum: used as an adjuvant to help stimulate an immune response and present in vaccines for DTaP, Tdap, hepatitis A, hepatitis B, Haemophilus influenzae type B (Hib), human papillomavirus (HPV), pneumococcal disease, and meningococcal disease.
  • Mercury: used in the form of thimerosal as a preservative and can be found in some multi-dose influenza vaccine preparations.
  • Phenol: used as an inactivating agent or preservative in certain vaccines including pneumococcal disease and Hib.
  • Formaldehyde: used as an inactivating ingredient and present as a residual in numerous vaccines including ones for DTaP, Tdap, hepatitis A, hepatitis B, influenza, and meningococcal disease.

While ATSDR typically develops toxicological profiles for substances based on environmental exposure like inhalation, ingestion, or skin exposure, ICAN emphasized that these particular toxins are injected directly into the bloodstream of millions of healthy children every year. What could be a higher priority for a toxicology assessment?

ICAN will be sure to update you if ATSDR selects any of the above substances for review.

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